Hormone Replacement Therapy In Menopause

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Hormone Replacement Therapy In Menopause

Question 1:

Which form of estrogen is the most potent?

A) Estrone

B) Estriol

C) Estradiol

D) All of the above are equally absorbed

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Hormone Replacement Therapy In Menopause

Question 2:

Which of the following is not a symptom associated with progesterone deficiency?

A) Weight gain

B) Infertility

C) Insomnia

D) Anxiety or depression

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Hormone Replacement Therapy In Menopause

Question 3:

The incidence of vasomotor symptoms increases during the transitional phase and peaks approximately how long after a woman’s last meses?

A) Immediately

B) 7 years

C) It is dependent upon the age at which a woman experiences menopause

D) 1 year

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Hormone Replacement Therapy In Menopause

Question 4:

Patients using HRT report improvements in which aspects?

A) Vasomotor symptoms

B) Sleep

C) Sexual function

D) All of the above

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Hormone Replacement Therapy In Menopause

Question 5:

For safe and effective use of HRT, which of the following must be considered?

A) Using the lowest effective dose

B) Using HRT for the shortest duration

C) Using gradual titration for relief of symptoms

D) All of the above

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Hormone Replacement Therapy In Menopause

Question 6:

Which of the following is not an FDA-approved indication for combined HRT in menopause?

A) Treatment of vasomotor symptoms

B) Dysfunctional uterine bleeding

C) Treatment of genitourinary syndrome of menopause

D) Prevention of osteoporosis

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Hormone Replacement Therapy In Menopause

Question 7:

Regular hormone level testing is highly advised in diagnosing menopause during the menopausal transition.

A) True

B) False

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Hormone Replacement Therapy In Menopause

Question 8:

Risk factors that can outweigh the benefits of HRT include history of breast, endometrial, or ovarian cancer, history of blood clot or stroke, smoking, and ____________ ?

A) Liver disease

B) Severe kidney impairment

C) Hypercholesterolemia

D) History of hypersensitivity reaction

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Hormone Replacement Therapy In Menopause

Question 9:

Transdermal estrogen bypasses the renal stage of metabolism, thereby negating the increased risk of blood clot compared to oral estrogen formulations.

A) True

B) False

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Hormone Replacement Therapy In Menopause

Question 10:

Which of the following medications is available as an oral combination product that may be prescribed for women with an intact uterus?

A) Duavee

B) ClimaraPro

C) Premarin

D) Menostar

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Hormone Replacement Therapy In Menopause

Question 11:

Which of the following is the recommended regimen for initiating Estrace vaginal cream?

A) Apply daily for 21 days, then 7 days off, then apply 1-3 times weekly for maintenance

B) Apply daily for 2 weeks, then apply twice weekly for maintenance

C) Apply 3 times weekly

D) Apply daily for 1-2 weeks, then apply 1-3 times weekly for maintenance

12 / 20

Hormone Replacement Therapy In Menopause

Question 12:

Which of the following is not an important counseling point regarding Vivelle-Dot patch application?

A) Missed patches should be applied as soon as remembered

B) Patches should be changed once weekly

C) Patches should be applied to clean, dry skin on the lower abdominal area

D) Patches should be removed prior to an MRI.

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Hormone Replacement Therapy In Menopause

Question 13:

Which of the following antidepressants, available as a lower dose than those typically seen for treating mood disorders, carries an FDA-approved indication for treatment of vasomotor symptoms?

A) Citalopram (Celexa)

B) Escitalopram (Lexapro)

C) Paroxetine (Brisdelle)

D) Venlafaxine (Effexor XR)

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Hormone Replacement Therapy In Menopause

Question 14:

Which of the following is not an important consideration with ospemifene (Osphena) therapy?

A) It is not indicated for mild symptoms of dyspareunia and should only be used short-term

B) It should be taken with food

C) It is safe to use in pregnancy

D) It is metabolized by CYP3A4 and CYP2C9 and should not be recommended in hepatic dysfunction

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Hormone Replacement Therapy In Menopause

Question 15:

The effects of complementary therapies such as soy-based foods and supplements have shown significant clinical benefit in alleviating hot flashes and vaginal dryness, and safety evidence makes these agents suitable first-line recommendations in symptomatic patients.

A) True

B) False

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Hormone Replacement Therapy In Menopause

Question 16:

Which of the following are safety concerns associated with custom-compounded therapy?

A) Products are not tested for purity and potency

B) Variation in inactive ingredients can introduce multiple sources for reactions or adverse effects

C) Absorption can be altered by vehicles used in the formulation, resulting in deviation from the intended dosage of the active medication

D) All of the above

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Hormone Replacement Therapy In Menopause

Question 17:

Custom-compounded hormonal therapy may be appropriate in certain cases, including all but which of the following situations?

A) When a different route of administration is preferred by a patient (i.e. sublingual tablets, troches, or suppositories)

B) Since it is recommended to regularly test hormone levels in patients taking compounded therapy, a targeted dose and stability in levels is easier to achieve than with traditional HRT

C) When the exact dosage needed is not commercially available

D) When intolerances to inactive ingredients or preservatives presents (i.e. peanut oil)

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Hormone Replacement Therapy In Menopause

Question 18:

Current recommendations suggest basing individualized discontinuation of HRT on symptom management rather than a woman’s age or therapy duration.

A) True

B) False

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Hormone Replacement Therapy In Menopause

Question 19:

The risk of which condition in HRT is significantly higher during initiation (first 1 to 2 years) and decreased thereafter?

A) Venous thromboembolism

B) Endometrial cancer

C) Cerebral stroke

D) Coronary artery disease

20 / 20

Hormone Replacement Therapy In Menopause

Question 20:

Which of the following is not an evidence-supported observed protective effect in estrogen-only therapy?

A) Decreased risk of colorectal cancer

B) Decreased risk of breast cancer

C) Decreased risk of coronary artery disease

D) Improved bone health and decreased risk of osteoporosis

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